Obesity is a global problem and is associated with a number of metabolic issues and health concerns. One of the many contributions and causes of weight gain is the inappropriate use of certain drugs or supplements that affect the normal metabolic or biochemical activities of the body, leading to fluctuations in body weight. One such drug is prednisone - a chemical derivative of the endogenous hormone cortisol. Cortisol, the stress hormone, is released by the adrenal gland in response to diseases and infections. However, in certain situations, such as inflammatory or autoimmune diseases, the demand significantly increases and is therefore fulfilled by synthetic forms of cortisol like prednisone.
Prednisone intake for extended periods of time is associated with weight gain. The causes of this weight gain include:
Clinical data suggests that a dosage of 0.75mg/kg/day for a period of more than 6 months can lead to considerable weight gain and the appearance of other cushingoid features[3].
Fortunately, weight gained caused by prednisone can be controlled by tapering the dosage to less than 10mg/day. If you are required to take prednisone for extended periods of time, speak to your doctor about alternative options. Other helpful remedies include:
One frustrating aspect of long-term prednisone therapy is futile weight loss efforts. A lot of people experience a great deal of difficulty in controlling weight gain by dietary management alone, and experts suggest that increasing physical activity can help in returning the metabolism to nearer normal levels.
Although it may be difficult to perform strenuous physical activity due to fatigue, low energy, pain or other symptoms of illness or prednisone therapy, you can definitely benefit from resistance training, strength training, aerobic exercise and yoga.
Weight gain is a known side effect of prednisone therapy, but you can adopt various strategies to control the weight gain. It is also recommended to see a dietitian for professional dietary guidelines to further manage any weight issues.